Recently Alain Badiou and Quentin Meillassoux have attacked the core of the phenomenological hermeneutic tradition: its commitment to the finitude of human understanding. If accurate, this critique threatens to render the whole tradition a topic of merely historical interest. Given the depth of the criticism, this essay aims to establish a provisional defense of hermeneutics. After briefly reviewing each critique, it is argued that Badiou and Meillassoux themselves face rather intractable difficulties. These difficulties, then, open the space for a hermeneutic (...) response, which is accomplished largely by drawing on the work of Paul Ricoeur. We close with a suggested program for hermeneutic thought. (shrink)

The present article aims to make good on Roland Barthe’s unfulfilled promise to provide an eidetic phenomenology for the photograph. Though the matter deserves consideration simply because no relevant account has yet been provided, the consequences of adumbrating eight eidetic features, we hope to show, bear directly on the phenomenology of time, the possibility of technological events, and the status of truth as what Heidegger called alētheia . Finally, and most importantly for the enterprise of phenomenological reflection, if we are (...) successful in this endeavor, we shall have established a new way to use eidetic phenomenologies: not for Husserl’s original aim of executing a rigorous science, but in a more Derridian spirit as a way to destabilize consensus. (shrink)

Shared leadership is not only about individual team members engaging in leadership, but also about team members adopting the complementary follower role. However, the question of what enables team members to fill in each of these roles and the corresponding influence of formal leaders have remained largely unexplored. Using a social network perspective allows us to predict both leadership and followership ties between team members based on considerations of implicit leadership and followership theories. From this social information processing perspective, we (...) identify individual team members’ political skill and the formal leaders’ empowering leadership as important qualities that facilitate the adoption of each the leader and the follower role. Results from a social network analysis in a R&D department with 305 realized leadership ties support most of our hypotheses. (shrink)

The transcription factor Pax5 is essential for the initial commitment of hematopoietic progenitors to the B cell lineage. Recently, our understanding of the lineage commitment process has been extended with the finding that Pax5 is also continuously required throughout B cell development to reinforce commitment, as inactivation of Pax5 in mature B cells results in their de‐differentiation to a progenitor stage that is capable of multi‐lineage potential.1 The reliance of B cell identity on a single gene is not without its (...) problems as the loss of Pax5 results in B cell malignancies in mouse models and mutation in human PAX5 is the most‐common genetic lesion in acute lymphoblastic leukemia. BioEssays 30:203–207, 2008. © 2008 Wiley Periodicals, Inc. (shrink)

Humans typically combine linguistic and nonlinguistic information to comprehend emotions. We adopted an emotion identification Stroop task to investigate how different channels interact in emotion communication. In experiment 1, synonyms of “happy” and “sad” were spoken with happy and sad prosody. Participants had more difficulty ignoring prosody than ignoring verbal content. In experiment 2, synonyms of “happy” and “sad” were spoken with happy and sad prosody, while happy or sad faces were displayed. Accuracy was lower when two channels expressed an (...) emotion that was incongruent with the channel participants had to focus on, compared with the cross-channel congruence condition. When participants were required to focus on verbal content, accuracy was significantly lower also when prosody was incongruent with verbal content and face. This suggests that prosody biases emotional verbal content processing, even when conflicting with verbal content and face simultaneously. Implications for multimodal communication and language evolution studies are discussed. (shrink)

ABSTRACTAdopting a temporally distant perspective on stressors reduces distress in adults. Here we investigate whether the extent to which individuals project themselves into the future influences distancing efficacy. We also examined modulating effects of age across adolescence and reactive aggression: factors associated with reduced future-thinking and poor emotion regulation. Participants read scenarios and rated negative affect when adopting a distant-future perspective, near-future perspective, or when reacting naturally. Self-report data revealed significant downregulation of negative affect during the distant-future condition, with a (...) similar though non-significant skin conductance pattern. Importantly, participants who projected further ahead showed the greatest distress reductions. While temporal distancing efficacy did not vary with age, participants reporting greater reactive aggression showed reduced distancing efficacy, and projected themselves less far into the future. Fi... (shrink)

ABSTRACTEvidence is currently mixed regarding the way in which cognitive conflict modulates the effect of emotion on task performance. The present study aimed to address methodological differences...

Alternatives to convenience sampling (CS) are needed for HIV/STI surveillance of most-at-risk populations in Latin America. We compared CS, time space sampling (TSS), and respondent driven sampling (RDS) for recruitment of men who have sex with men (MSM) and transgender women (TW) in Lima, Peru. During concurrent 60-day periods from June-August, 2011, we recruited MSM/TW for epidemiologic surveillance using CS, TSS, and RDS. A total of 748 participants were recruited through CS, 233 through TSS, and 127 through RDS. The TSS (...) sample included the largest proportion of TW (30.7 %) and the lowest percentage of subjects who had previously participated in HIV/STI research (14.9 %). The prevalence of newly diagnosed HIV infection, according to participants' self-reported previous HIV diagnosis, was highest among TSS recruits (17.9 %) compared with RDS (12.6 %) and CS (10.2 %). TSS identified diverse populations of MSM/TW with higher prevalences of HIV/STIs not accessed by other methods. (shrink)

Abordaré la crítica de Axel Honneth a la primera Escuela de Frankfurt y su aparente omisión de Herbert Marcuse. Defenderé a Marcuse contra algunas de las críticas hechas por Honneth a la teoría crítica temprana de la Escuela de Frankfurt. Luego argumentaré que Marcuse siempre estuvo en busca de una subjetividad radical, incluso cuando advirtió contra los mecanismos unidimensionales en curso de producción de sujetos. Finalmente, mostraré que Honneth también construye su proyecto en torno a la búsqueda de una subjetividad (...) radical, pero aborda el problema a través de una teoría de la intersubjetividad que complementa el proyecto de Marcuse. (shrink)

The concept of "life" has always been part of the basic philosophical topoi. In Greek antiquity, the question of what constitutes a "good" or "successful" life was regarded as a fundamental question of philosophy. As a result, early philosophers engaged in practice-oriented philosophizing which regarded philosophy as a form of life. In Modern philosophy, the term "life" became a technical term in different philosophical traditions such as the philosophy of life, philosophy of existence, and phenomenology. This volume brings together contributions (...) in German and French that explore the concept of "life" historically and systematically, focusing on metaphysical, anthropological, and ethical issues. (shrink)

Notre article propose d’explorer la réception de Pierre Poiret au sein du piétisme radical en Allemagne. Dans ce milieu spirituel a émergé une traduction allemande de l’Œconomie Divine (1687) (7 vol. 1735-1742). Nous souhaitons donner quelques éclairages sur la réalisation de ce projet, les personnes qui y ont été associées, ainsi que sur la manière dont le texte de Poiret a été transposé en langue allemande. Poiret et ses traducteurs piétistes partagent la conviction que la vérité religieuse n’est accessible que (...) par l’illumination divine. Mais la tension entre l’inspiration divine de la vérité et son agencement systématique et rationnel dans le volumineux traité de Poiret se trouve encore renforcée par les stratégies érudites mises en place par les traducteurs, notamment par Johann Christoph Edelmann qui se muera de piétiste radical en représentant des Lumières radicales. (shrink)

SEBASTIÁN RUDAS | : Moralized secularism is the view that “secularism” is defined in relation to certain moral values. Jocelyn Maclure and Charles Taylor’s “liberal pluralism” is an influential version of moralized secularism, for it states that freedom of conscience and equal respect are the fundamental moral values of secularism. I present the objection that secularism is a redundant category because it carries no distinctive normative content that cannot be found in the more general, and less divisive, terminology of liberalism (...) and democracy. In order to avoid this objection, I argue for conceiving secularism in a nonmoralized way. According to my view, secularism refers solely to the institutional arrangements that a state can put in place in order to address conflicts with organized religion that might emerge at the moment of advancing its ideological political project. Through this interpretation, it is possible to conceptualize expressions of secularism that are either not liberal or not motivated by the acknowledgment of new forms of pluralism as being the prime challenge a state faces for advancing its political project. As the redundancy objection shows, this is a possibility that moralized accounts of secularism preclude. | : Les versions moralisées de la laïcité définissent la « laïcité » par rapport à des valeurs morales. Le « pluralisme libéral » de Jocelyn Maclure et Charles Taylor est un exemple influent de la laïcité moralisée, car il affirme que la liberté de conscience et l’égal respect sont les valeurs morales fondamentales de la laïcité. Je propose l’objection selon laquelle la laïcité est une catégorie redondante, car elle ne comporte aucun contenu normatif distinctif qui ne peut être trouvé dans la terminologie plus générale et moins controversée du libéralisme et de la démocratie. Pour répondre à cette objection, je soutiens qu’il faut concevoir la laïcité de manière non moralisée. Selon moi, la laïcité se réfère seulement aux arrangements institutionnels qu’un État peut mettre en place pour répondre aux conflits avec les religions organisées qui pourraient surgir au moment de faire avancer son projet politique idéologique. Dans cette interprétation, il est possible de conceptualiser des expressions de laïcité qui sont non libérales, ou qui ne sont pas motivées par la reconnaissance de nouvelles formes de pluralisme à titre de principal défi auquel un État est confronté pour faire avancer son projet politique. Comme le montre l’objection de redondance, c’est une possibilité que la laïcité moralisée exclut. (shrink)

The 2018 eligibility regulation for female competitors with differences of sexual development (DSD) issued by World Athletics requires competitors with DSD with blood testosterone levels at or above 5 nmol/L and sufficient androgen sensitivity to be excluded from competition in certain events unless they reduce the level of testosterone in their blood. This paper formalises and then critically assesses the fairness-based argument offered in support of this regulation by the federation. It argues that it is unclear how the biological advantage (...) singled out by the regulation as an appropriate target for diminishment, is relevantly different from other biological advantages that athletes may enjoy, and specifically that Sigmund Loland’s recent attempt to drive a wedge between heightened levels of blood testosterone and other biological advantages fails. The paper also suggests that even if heightened blood testosterone levels do differ relevantly from other types of biological advantage, the regulation is further challenged by studies indicating that athletes with blood testosterone at the high end of the normal range have a competitive advantage over athletes with blood testosterone levels at the low end of it. Finally, the paper contends that the premises of the fairness-based argument do not unequivocally support the conclusion that DSD athletes with heightened levels of testosterone should diminish those levels, since, just as powerfully, they support allowing athletes with normal levels of testosterone to use performance-enhancing drugs in the name of fairness. (shrink)

The comorbidity of chronic pain and opioid addiction is a serious problem that has been growing with the practice of prescribing opioids for chronic pain. Neuroimaging research has shown that chronic pain and opioid dependence both affect brain structure and function, but this is the first study to evaluate the neurophysiological alterations in patients with comorbid chronic pain and addiction. Eighteen participants with chronic low back pain and opioid addiction were compared with eighteen age- and sex-matched healthy individuals in a (...) pain-induction fMRI task. Unified structural equation modeling (SEM) with Lagrange multiplier (LM) testing yielded a network model of pain processing for patient and control groups based on 19 a priori defined regions. Tests of differences between groups on specific regression parameters were determined on a path-by-path basis using z-tests corrected for the number of comparisons. Patients with the chronic pain and addiction comorbidity had increased connection strengths; many of these connections were interhemispheric and spanned regions involved in sensory, affective, and cognitive processes. The affected regions included those that are commonly altered in chronic pain or addiction alone, indicating that this comorbidity manifests with neurological symptoms of both disorders. Understanding the neural mechanisms involved in the comorbidity is crucial to finding a comprehensive treatment, rather than treating the symptoms individually. (shrink)

Among the extensive correspondence of Timothy I, Catholicos of the Church of the East, are two letters which refer to his collobaration in a translation of Aristotle's Topics into Syriac and Arabic, commissioned by the Caliph al-Mahdī. An annotated English translation of both letters is provided. Dans la volumineuse correspondance de Timothée I, Catholicos de l'Église orientale, deux lettres renvoient à sa collaboration à la traduction des Topiques d'Aristote en syriaque et en arabe, commandée par le Calife al-Mahdī. On trouvera (...) ici la traduction annotée en anglais de ces deux lettres. (shrink)

Short description: Part A : Philosophy, Literature, and Knowledge – Chapter I : Idealism and the Absolute – A. J. B. Hampton: “Herzen schlagen und doch bleibet die Rede zurück?” Philosophy, poetry, and Hölderlin’s development of language suffi cient to the Absolute – P. Sabot: L’absolu au miroir de la littérature. Versions de l’Hégélianisme’ chez Villiers de l’Isle Adam et chez Mallarmé – P. Gordon: Nietzsche’s Critique of the Kantian Absolute – Chapter II: Philosophy and Style – J.-P. Larthomas: Le (...) cas Kierkegaard (1813-1855) ou l’écriture comme dialectique de l’écoute – S. Hüsch: Style et signifi cation. Intériorité et communication indirecte chez Søren Kierkegaard – A. Milon: La question du style en philosophie: la grammaire non-style – C. Van Lerberghe: La question du style dans la phénoménologie asubjective de Jan Patocka – Chapter III: Poetry and Philosophy – J.-B. Dussert: Martin Heidegger en ses poèmes – C. de Roche: The poem and the monad: On the reception of Leibniz‘ monadology in Paul Celan’s poetics – M. de Jesus Cabral: Entre théâtre et philosophie : notes sur la poétique de Maurice Maeterlinck – Chapter IV : Literature, Philosophy, and (new) Mythology – A. Martinengo: La raison hors de soi. Herméneutique et mythe chez Paul Ricoeur – G. Boggio Marzet Tremoloso: Démythologisation comme acte mythopoïétique: le cas de Jason de Elisabeth Porquerol. – G. Coulter: Jean Baudrillard: The Literary / Poetic Philosopher – Chapter V : Literature and Ethics – J. Azoulai: L’Éthique de Spinoza dans Bouvard et Pécuchet: un vertige philosophique et littéraire – I. Vendrell: Can Literature be Moral Philosophy? A sceptical view on the Ethics of Literary Empathy – F. Picon: Envisager Todorov: Poétique, éthique et humanisme contemporain – Chapter VI : Philosophy and Textuality – E. Lecler: La littérature : la mort de la philosophie – J. A. Gosetti- Ferencei: Writing in Philosophy and the Literature and Philosophy of Writing (Plato, Mann, Blanchot) –W. Cristaudo: Bringing Back Character and Grammar: Freeing Literature from Excessive Reliance on Philosophy and Theory – C. Alfano: Parenthesising Cracks into the Ground of Philosophy: The Textuality of Stanley Cavell’s Philosophical Writing – Part B: Perspectives of a Dialogue between Philosophy and Literature: Philosophical Refl ections in Literary Creation – Chapter VII : Philosophical Dialogue and Literature – A. Baillot: Tieck et Solger, un dialogue philosophicolittéraire – V. Altachina: Le dialogue philosophique chez Diderot et chez Dostoïevski – Chapter XIII : Bergsonien Infl uences in Literature – C. Dewas: Bergson et Katzantzakis. Les limites du langage comme condition d’une métaphysique de la littérature – E. Pesenti Rossi: La philosophie à l’épreuve de la poésie : Bergson et Ungaretti – Chapter IX : Wittgenstein and Literature – G. Valdemarca: La revanche du sens commun : Wittgenstein, Musil et la chute de la certitude – A. Leaker: From the ‘numinous glow’ to ‘gut squalor’: Transcendence and the Ordinary in Wittgenstein and Don DeLillo’s Underworld – A. den Dulk: Wallace and Wittgenstein: Literature as Dialogue Concerning the Real World – Chapter X: Borges and Semprun: Writers and Philosophers – J.-F. Mattéi: Borges et la philosophie – T. Capmartin: Voyage au bout de la représentation dans Fictions: Quelques remarques ménardiennes sur Borges et le stoïcisme – V. Capdevielle- Hounieu: Jorge Semprún et l’hybridation du littéraire et du philosophique : pour une ‘fi ction essayistique’ – Chapter XI : Literary (Mis-) Readings of Philosophy – P. Lasarte: Misreadings of Arthur Schopenhauer in Sin Rumbo by Eugenio Cambaceres – S. Roldan: Qu’est-ce qui est fort comme la mort selon Maupassant? La détermination ultime d’Olivier Vertin vue sous l’angle de Schopenhauer – B. Nickel: L’infl uence de Ludwig Wittgenstein (1889–1951) sur la poésie concrète – Chapter XII: The Impact of Philosophy on 20th Century Literature and Poetry – B. Ertugrul: Walter Benjamin et Ingeborg Bachmann entre littérature et philosophie – J. Leclercq / M. Watthee-Delmotte: Michel Henry : pour un langage de la subjectivité. La pensée du roman Le Fils du roi – J. Hobus: “The happiness of the concentration camps”: Reading Imre Kertész’ Novel Fatelessness with Albert Camus’ Concept of the Absurd – S. Frogel: Man without God: Nietzsche, Kafka and Camus Der Herausgeber Sébastian Hüsch, Studium der Philosophie, Geschichte,. (shrink)

Although the topic of value congruence has attracted considerable attention from researchers and practitioners, evidence for the link between person–supervisor value congruence and followers’ reactions is less robust than often assumed. This study addresses three central issues in our understanding of person–supervisor value congruence by assessing the impact of objective person–supervisor value congruence rather than subjective value congruence, by examining the differential effects of value congruence in strongly versus moderately held values, and by exploring perceived empowerment as a central mediating (...) mechanism. Results of a multi-source study comprising 116 person–supervisor dyads reveal that objective value congruence relates to followers’ job satisfaction and affective commitment and that this link can be explained by followers’ perceived empowerment. Moreover, polynomial regression and response surface analyses reveal that congruence effects vary with the importance that leaders and followers ascribe to a certain value: Congruency in strongly held values have more robust relations with followers’ outcomes than congruence in moderately held values. (shrink)

Job crafting has been established as a bottom-up work design instrument for promoting health and well-being in the workplace. In recent years, the concepts of job crafting have been applied to the university student context, proving to be positively related to student well-being. Building on person-centered analyses from the employment context, we assessed approach study crafting strategy combinations and the relationships to students’ exhaustion, study engagement, and general well-being. Data from 2,882 German university students were examined, collected online during the (...) summer term in 2020. Using latent profile analysis, we found five distinct crafting groups, which showed discriminate validity with regard to emotional exhaustion, engagement, and well-being. The results underscore the positive role of study crafting for students’ health and well-being. They further indicate a less important role of increasing social resources for emotional exhaustion when combined with a moderate increase in structural resources and a moderate increase in challenging demands. Our findings imply that interventions to promote study crafting should be considered to promote student health and well-being. (shrink)

En s’appuyant sur une enquête de terrain concernant un établissement de la filière automobile, cet article cherche à montrer que le temps de travail a adopté un caractère flexible et fragmenté à la suite de transformations concomitantes de l’organisation du travail et des relations professionnelles. Ce temps est articulé au flux et au volume de production, ce qui le rend moins régulier et prévisible pour les salariés. Leur temps de travail peut ainsi varier à la hausse ou à la baisse (...) selon des contraintes de marché ou des aléas industriels. À cette flexibilité s’ajoute la désynchronisation du temps des différents ateliers et équipes à l’usine. En conséquence, les salariés et leurs représentants ont de moins en moins de prise sur un temps de travail qui semble s’imposer à eux, de l’extérieur. Face à cette situation, les marges de revendication des élus du personnel se réduisent. Ils tentent de redonner une certaine régularité et synchronicité au temps de travail quand il ne s’agit pas de négocier des contreparties salariales. Les transformations de l’organisation du travail en cours remettent donc en cause – mais de façon discrète – l’une des mesures dominantes du travail en régime fordien en réformant profondément les modalités de négociation sur le temps de travail. (shrink)

The 'late' Foucault and his purported 'return to the subject' is a much discussed issue. Over the past twenty years, various suggestions have been made as to how to integrate Foucault's ethics into his oeuvre as a whole. This paper holds that there is a 'conceptual continuity', rather than a break, between Foucault's earlier works on normalizing power, and his later works on ethical self-constitution. On the basis of a conceptual framework, which is developed in Section II, a reading of (...) two themes concerning certain practices of the self is offered in the following sections (namely, dietetics and spiritual guidance). The material, drawn from the recently published lecture series L'herméneutique du sujet as well as from other published works, is related back to Foucault's ideas on the process of 'subjectivation', in order to support the claim that 'fabrication' and 'self-constitution' are but two aspects of subjectivation. Keywords: late Foucault, ethics, practices of the self, self-constitution, discipline, power, surveillance, spiritual guidance, meditation, parrhesia, dietetics, art of living, aesthetics of existence, return of the subject, subjectivation, relation to self. (shrink)

Normal 0 21 Cet article s’attache à montrer la persistance au XVIIIe siècle d’un problème né en sol cartésien – le solipsisme – afin d’atténuer la distinction trop abrupte que l’on fait habituellement entre le rationalisme classique et l’empirisme des Lumières, notamment au plan épistémologique. Après avoir montré l’importance du débat au XVIIIe siècle et répertorié les arguments pro et contra la position solipsiste, l’article se conclut par un plaidoyer en faveur d’une relecture de la philosophie des Lumières, et propose (...) de relier le pessimisme épistémologique qui caractérise les grandes théories philosophiques de la fin du XVIIIe siècle à la prégnance du cartésianisme sur un siècle qui croyait pourtant s’être débarrassé de l’esprit de système du siècle précédent. (shrink)

ABSTRACTTask-irrelevant emotional expressions are known to capture attention, with the extent of “emotional capture” varying with psychopathic traits in antisocial samples. We investigated whether this variation extends throughout the continuum of psychopathic traits in a community sample. Participants searched for a target face among facial distractors. As predicted, angry and fearful faces interfered with search, indicated by slower reaction times relative to neutral faces. When fear appeared as either target or distractor, diminished emotional capture was seen with increasing affective-interpersonal psychopathic (...) traits. However, moderation analyses revealed that this was only when lifestyle-antisocial psychopathic traits were low, consistent with evidence suggesting that these two facets of psychopathic traits display opposing relationships with emotional reactivity. Anxiety did not show the predicted relationships with emotional capture effects. Findings show... (shrink)

Prolonging working hours and presenteeism have been conceptualized as self-endangering coping behaviors in employees, which are related to health impairment. Drawing upon the self-regulation of behavior model, the goal achievement process, and Warr's vitamin model, we examined the antecedents and moderation effects regarding quantitative demands, autonomy, emotion regulation, and self-motivation competence of university students' self-endangering coping behaviors. Results from a cross-sectional survey of 3,546 German university students indicate that quantitative demands are positively related and autonomy has a u-shape connection with (...) self-endangering coping. Emotion regulation was shown to be a protective factor for prolonging working hours. Moreover, self-motivation moderated the relationship between quantitative demands and prolonging of working hours, but not in the assumed direction. Self-motivation showed a systematic positive relationship with prolonging of working hours, but no relationship with presenteeism. Autonomy moderated the relationship of quantitative demands with both self-endangering behaviors. We found no moderating effects for emotion regulation of quantitative demands or autonomy and self-endangering behaviors. Besides further practical implications, the results suggest that lecturers should design their courses accordingly with less time pressure and university students should be trained in the use of autonomy. (shrink)

Résumé L'article vise à montrer que le langage est intimement lié au monde social et que la clarification d'une telle relation dépend du fait de considérer sur un même plan les énoncés et les actions, ce qui conduit à considérer l'énonciation par le langage comme un type de comportement partagé. Cela signifie que la langue ne sert pas seulement les besoins de la vie sociale en tant que moyen d'intercompréhension. De façon relativement autonome, le langage fonctionne dans des conditions de (...) réalisation qui sont des relations sociales très segmentées et hiérarchisées. L'hypothèse est qu'il est nécessaire, comme point de départ de l'analyse du caractère social du langage, de reconnaître la valeur performative qu'ont les énoncés, du fait qu'ils contiennent, dans le domaine des actes de langage, un certain pouvoir effectif ajusté aux conditions sociales qui détermine leur énonciation. Resumen El artículo tiene el objetivo de mostrar que el lenguaje está íntimamente vinculado con el mundo social y que aclarar tal relación depende de considerar en un mismo plano de dependencia a los enunciados y a las acciones - lo que lleva a considerar al lenguaje como un tipo de comportamiento compartido. Eso quiere decir que el lenguaje no solo sirve a las necesidades de la vida social como medio de intercomprensión. Sobre un fondo relativamente autónomo -caracterizable en las consideraciones sobre los matices semánticos introducidos por las significaciones implícitas- el lenguaje funciona en condiciones de realización que son relaciones sociales altamente segmentadas y jerarquizadas. La hipótesis es que el lenguaje se realiza socialmente en la medida en que facilita a los individuos una forma de contacto. Pero también insistimos en que como punto de partida para el análisis del carácter social del lenguaje es necesario reconocer el valor performativo que tienen los enunciados en cuanto comportan, en el ámbito de los hechos del habla, un cierto poder realizativo ajustado a condiciones sociales que determinan los caminos de tal realización. (shrink)

https://revistes.uab.cat/enrahonar/article/view/v57-luft.

The rapid evolution of drug resistance remains a major obstacle for HIV therapy. The capacity of the virus for recombination is widely believed to facilitate the evolution of drug resistance. Here, we challenge this intuitive view. We develop a population genetic model of HIV replication that incorporates the processes of mutation, cellular superinfection, and recombination. We show that cellular superinfection increases the abundance of low fitness viruses at the expense of the fittest strains due to the mixing of viral proteins (...) during virion assembly. Moreover, we argue that whether recombination facilitates the evolution of drug resistance depends critically on how resistance mutations interact to determine viral fitness. Contrary to the commonly held belief, we find that, under the most plausible biological assumptions, recombination is expected to slow down the rate of evolution of multi‐drug‐resistant virus during therapy. BioEssays 26:180–188, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

La paix entre l’État et les FARC en 2016 a fortement limité le nombre de victimes de violences mais ces dernières risquent de repartir de plus belle. La moitié des guérilleros ont été désarmés par l’ONU, ce qui laisse le pays sans encadrement territorial pour s’opposer au narcotrafic. Les anciens FARC sont assassinés par de nouvelles structures criminelles en train d’occuper le terrain.